About the Authors
- Minerva M. Carrasquillo
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Contributed equally to this work with: Minerva M. Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen
Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Olivia Belbin
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Contributed equally to this work with: Minerva M. Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen
Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Fanggeng Zou
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Contributed equally to this work with: Minerva M. Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen
Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Mariet Allen
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Contributed equally to this work with: Minerva M. Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen
Affiliations Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America, Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Nilufer Ertekin-Taner
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Affiliations Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America, Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Morad Ansari
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Affiliation Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Samantha L. Wilcox
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Mariah R. Kashino
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Li Ma
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Linda H. Younkin
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Samuel G. Younkin
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Curtis S. Younkin
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Toros A. Dincman
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Melissa E. Howard
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Chanley C. Howell
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Chloe M. Stanton
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Christopher M. Watson
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Michael Crump
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Veronique Vitart
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Affiliation Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Caroline Hayward
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Affiliation Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Nicholas D. Hastie
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Affiliation Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Igor Rudan
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Current address: Gen-info Ltd., Zagreb, Croatia
Affiliations Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia, Centre for Clinical Medical Research, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia
- Harry Campbell
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Affiliation Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom
- Ozren Polasek
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Current address: Gen-info Ltd., Zagreb, Croatia
Affiliations Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom, Centre for Clinical Medical Research, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia
- Kristelle Brown
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Affiliation School of Molecular Medical Sciences, Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom
- Peter Passmore
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Affiliation Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
- David Craig
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Affiliation Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
- Bernadette McGuinness
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Affiliation Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
- Stephen Todd
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Affiliation Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom
- Patrick G. Kehoe
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Affiliation Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol, United Kingdom
- David M. Mann
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Affiliation Greater Manchester Neurosciences Centre, University of Manchester, Manchester, United Kingdom
- A. David Smith
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Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
- Helen Beaumont
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Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
- Donald Warden
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Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
- Clive Holmes
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Affiliation Memory Assessment and Research Centre, University of Southampton, Southampton, United Kingdom
- Reinhard Heun
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Affiliation Division of Neuroscience, University of Birmingham, Birmingham, United Kingdom
- Heike Kölsch
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Affiliation Department of Psychiatry, University of Bonn, Bonn, Germany
- Noor Kalsheker
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Affiliation School of Molecular Medical Sciences, Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom
- V. Shane Pankratz
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Affiliation Department of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, United States of America
- Dennis W. Dickson
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Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Neill R. Graff-Radford
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Affiliation Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Ronald C. Petersen
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Affiliation Department of Neurology and the Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
- Alan F. Wright
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Affiliation Medical Research Council (MRC) Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
- Steven G. Younkin
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* E-mail: younkin.steven@mayo.edu
Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
- Kevin Morgan
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Affiliation School of Molecular Medical Sciences, Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: MMC OB FZ MA LHY AW SGY KM. Performed the experiments: MMC OB FZ MA MA SLW MRK LM LHY TAD MEH CCH CMS CMW MC VV CH KB. Analyzed the data: MMC OB FZ MA NET MA SLW MRK SGY CSY VV CH VSP SGY KM. Contributed reagents/materials/analysis tools: MMC NH IR HC OP PP DC BM ST PGK DM ADS HB DW CH RH HK NK DWD NRGR RCP SGY KM. Wrote the paper: MMC OB FZ MA NET SGY KM. Principal investigator: SGY KM.