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Research Article

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

  • Francisco Pan-Montojo mail,

    pan-montojo@mpi-cbg.de (FP-M); richard.funk@tu-dresden.de (RHWF)

    Affiliations: Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany, Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany, International Max-Planck Research School, Max-Planck Institute for Cell Biology and Genetics, Dresden, Germany

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  • Oleg Anichtchik,

    Affiliation: Center for Brain Repair, University of Cambridge, Cambridge, United Kingdom

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  • Yanina Dening,

    Affiliation: Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Lilla Knels,

    Affiliation: Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Stefan Pursche,

    Affiliation: Department of Internal Medicine I, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Roland Jung,

    Affiliation: Experimental Center, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Sandra Jackson,

    Affiliation: Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Gabriele Gille,

    Affiliation: Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Maria Grazia Spillantini,

    Affiliation: Center for Brain Repair, University of Cambridge, Cambridge, United Kingdom

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  • Heinz Reichmann,

    Affiliation: Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Richard H. W. Funk mail

    pan-montojo@mpi-cbg.de (FP-M); richard.funk@tu-dresden.de (RHWF)

    Affiliation: Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pone.0008762

About the Authors

Francisco Pan-Montojo, Yanina Dening, Lilla Knels, Richard H. W. Funk
Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Francisco Pan-Montojo, Sandra Jackson, Gabriele Gille, Heinz Reichmann
Department of Neurology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Oleg Anichtchik, Maria Grazia Spillantini
Center for Brain Repair, University of Cambridge, Cambridge, United Kingdom
Stefan Pursche
Department of Internal Medicine I, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Roland Jung
Experimental Center, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Francisco Pan-Montojo
International Max-Planck Research School, Max-Planck Institute for Cell Biology and Genetics, Dresden, Germany

Corresponding Authors

Competing Interests

Francisco Pan-Montojo has a patent application pending for this animal model (Application number PCT/EP 2009/005688). This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors (http://www.plosone.org/static/policies.action#sharing).

Author Contributions

Conceived and designed the experiments: FJPM. Performed the experiments: FJPM OA. Analyzed the data: FJPM YFD SP SJ GG MGS RF. Contributed reagents/materials/analysis tools: LK SP RJ SJ GG MGS HR RF. Wrote the paper: FJPM OA MGS RF.