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Research Article

A Role for BK Channels in Heart Rate Regulation in Rodents

  • Wendy L. Imlach,

    Affiliations: AgResearch, Grasslands Research Centre, Palmerston North, New Zealand, Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand

    Current address: Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, United States of America

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  • Sarah C. Finch,

    Affiliation: AgResearch, Ruakura Research Centre, Hamilton, New Zealand

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  • John H. Miller,

    Affiliation: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand

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  • Andrea L. Meredith,

    Affiliation: Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Julie E. Dalziel mail

    julie.dalziel@agresearch.co.nz

    Affiliation: AgResearch, Grasslands Research Centre, Palmerston North, New Zealand

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  • Published: January 14, 2010
  • DOI: 10.1371/journal.pone.0008698

About the Authors

Wendy L. Imlach, Julie E. Dalziel
AgResearch, Grasslands Research Centre, Palmerston North, New Zealand
Sarah C. Finch
AgResearch, Ruakura Research Centre, Hamilton, New Zealand
John H. Miller
School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
Andrea L. Meredith
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Wendy L. Imlach
Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand

Corresponding Author

Email: julie.dalziel@agresearch.co.nz

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WLI SCF JHM ALM JED. Performed the experiments: WLI. Analyzed the data: WLI JED. Contributed reagents/materials/analysis tools: SCF. Wrote the paper: WLI SCF JHM ALM JED. Isolated the alkaloid compounds and synthesized derivatives: SCF. Supervised the isolated heart experiments: JHM. Supervised the whole animal experiments and generated the Kcnma1−/− mice: ALM.