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Research Article

The Virion Host Shut-Off (vhs) Protein Blocks a TLR-Independent Pathway of Herpes Simplex Virus Type 1 Recognition in Human and Mouse Dendritic Cells

  • Christopher R. Cotter equal contributor,

    equal contributor Contributed equally to this work with: Christopher R. Cotter, Marie L. Nguyen

    Affiliation: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Marie L. Nguyen equal contributor,

    equal contributor Contributed equally to this work with: Christopher R. Cotter, Marie L. Nguyen

    Affiliations: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Microbiology and Immunology, Des Moines University, Des Moines, Iowa, United States of America

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  • Jacob S. Yount,

    Affiliation: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Carolina B. López,

    Affiliation: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • John A. Blaho,

    Affiliation: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America

    X
  • Thomas M. Moran mail

    thomas.moran@mssm.edu

    Affiliation: Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: February 18, 2010
  • DOI: 10.1371/journal.pone.0008684

About the Authors

Christopher R. Cotter, Marie L. Nguyen, Jacob S. Yount, Carolina B. López, John A. Blaho, Thomas M. Moran
Department of Microbiology and Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America
Marie L. Nguyen
Department of Microbiology and Immunology, Des Moines University, Des Moines, Iowa, United States of America

Corresponding Author

Email: thomas.moran@mssm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC MLN TMM. Performed the experiments: CC MLN JSY. Analyzed the data: CC MLN JSY. Contributed reagents/materials/analysis tools: JAB. Wrote the paper: CC. Assisted in writing the manuscript: TMM CL. Helped edit the manuscript: MLN JSY JAB.