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Research Article

Differential Impact of Tumor Suppressor Pathways on DNA Damage Response and Therapy-Induced Transformation in a Mouse Primary Cell Model

  • A. Kathleen McClendon,

    Affiliation: Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Jeffry L. Dean,

    Affiliation: Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Adam Ertel,

    Affiliation: Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Erik S. Knudsen mail

    eknudsen@kimmelcancercenter.org

    Affiliation: Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Published: January 01, 2010
  • DOI: 10.1371/journal.pone.0008558

About the Authors

A. Kathleen McClendon, Jeffry L. Dean, Adam Ertel, Erik S. Knudsen
Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: eknudsen@kimmelcancercenter.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKM ESK. Performed the experiments: AKM JLD AE. Analyzed the data: AKM JLD AE. Wrote the paper: AKM ESK.