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Research Article

Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A Streptococcus

  • Anna L. Cogen,

    Affiliations: Division of Dermatology, University of California San Diego, San Diego, California, United States of America, Department of Bioengineering, University of California San Diego, San Diego, California, United States of America

    X
  • Kenshi Yamasaki,

    Affiliation: Division of Dermatology, University of California San Diego, San Diego, California, United States of America

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  • Jun Muto,

    Affiliation: Division of Dermatology, University of California San Diego, San Diego, California, United States of America

    X
  • Katheryn M. Sanchez,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States of America

    X
  • Laura Crotty Alexander,

    Affiliation: Department of Pediatrics, School of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Jackelyn Tanios,

    Affiliation: Division of Dermatology, University of California San Diego, San Diego, California, United States of America

    X
  • Yuping Lai,

    Affiliation: Division of Dermatology, University of California San Diego, San Diego, California, United States of America

    X
  • Judy E. Kim,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States of America

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  • Victor Nizet,

    Affiliations: Department of Pediatrics, School of Medicine, University of California San Diego, San Diego, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

    X
  • Richard L. Gallo mail

    rgallo@ucsd.edu

    Affiliations: Division of Dermatology, University of California San Diego, San Diego, California, United States of America, Department of Pediatrics, School of Medicine, University of California San Diego, San Diego, California, United States of America

    X
  • Published: January 05, 2010
  • DOI: 10.1371/journal.pone.0008557

About the Authors

Anna L. Cogen, Kenshi Yamasaki, Jun Muto, Jackelyn Tanios, Yuping Lai, Richard L. Gallo
Division of Dermatology, University of California San Diego, San Diego, California, United States of America
Anna L. Cogen
Department of Bioengineering, University of California San Diego, San Diego, California, United States of America
Katheryn M. Sanchez, Judy E. Kim
Department of Chemistry and Biochemistry, University of California San Diego, San Diego, California, United States of America
Laura Crotty Alexander, Victor Nizet, Richard L. Gallo
Department of Pediatrics, School of Medicine, University of California San Diego, San Diego, California, United States of America
Victor Nizet
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America

Corresponding Author

Email: rgallo@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALC KY JEK RLG. Performed the experiments: ALC JM. Analyzed the data: ALC KMS RLG. Contributed reagents/materials/analysis tools: KMS LECA JT YL JEK VN RLG. Wrote the paper: ALC VN RLG.