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Research Article

A Statistical Method for the Detection of Alternative Splicing Using RNA-Seq

  • Liguo Wang,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Yuanxin Xi,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Jun Yu,

    Affiliation: Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China

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  • Liping Dong,

    Affiliations: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Laising Yen,

    Affiliations: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Wei Li mail

    WL1@bcm.edu

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: January 08, 2010
  • DOI: 10.1371/journal.pone.0008529

About the Authors

Liguo Wang, Yuanxin Xi, Wei Li
Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
Liguo Wang, Yuanxin Xi, Liping Dong, Laising Yen, Wei Li
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Liping Dong, Laising Yen
Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
Jun Yu
Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China

Corresponding Author

Email: WL1@bcm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LW YFX WL. Performed the experiments: LD LY. Analyzed the data: LW YFX WL. Contributed reagents/materials/analysis tools: JY. Wrote the paper: LW LY WL.