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Research Article

Development of Functional Human NK Cells in an Immunodeficient Mouse Model with the Ability to Provide Protection against Tumor Challenge

  • Amanda Kwant-Mitchell,

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

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  • Elishka A. Pek,

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

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  • Kenneth L. Rosenthal equal contributor,

    equal contributor Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

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  • Ali A. Ashkar equal contributor mail

    equal contributor Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

    ashkara@mcmaster.ca

    Affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

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  • Published: December 21, 2009
  • DOI: 10.1371/journal.pone.0008379

About the Authors

Amanda Kwant-Mitchell, Elishka A. Pek, Kenneth L. Rosenthal, Ali A. Ashkar
Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Corresponding Author

Email: ashkara@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAA. Performed the experiments: AKM EAP AAA. Analyzed the data: AKM EAP. Contributed reagents/materials/analysis tools: KLR. Wrote the paper: AKM AAA.