Development of Functional Human NK Cells in an Immunodeficient Mouse Model with the Ability to Provide Protection against Tumor Challenge

Amanda Kwant-Mitchell; Elishka A. Pek; Kenneth L. Rosenthal; Ali A. Ashkar

doi:10.1371/journal.pone.0008379

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Open Access

Peer-reviewed

Research Article

Development of Functional Human NK Cells in an Immunodeficient Mouse Model with the Ability to Provide Protection against Tumor Challenge

Amanda Kwant-Mitchell,

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
⨯
Elishka A. Pek,

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
⨯
Kenneth L. Rosenthal ,

Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
⨯
Ali A. Ashkar

Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

* E-mail: ashkara@mcmaster.ca

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
⨯

Development of Functional Human NK Cells in an Immunodeficient Mouse Model with the Ability to Provide Protection against Tumor Challenge

Amanda Kwant-Mitchell,
Elishka A. Pek,
Kenneth L. Rosenthal,
Ali A. Ashkar

Published: December 21, 2009
https://doi.org/10.1371/journal.pone.0008379

About the Authors

Amanda Kwant-Mitchell

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Elishka A. Pek

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Kenneth L. Rosenthal

Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Ali A. Ashkar

Contributed equally to this work with: Kenneth L. Rosenthal, Ali A. Ashkar

* E-mail: ashkara@mcmaster.ca

Affiliation Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAA. Performed the experiments: AKM EAP AAA. Analyzed the data: AKM EAP. Contributed reagents/materials/analysis tools: KLR. Wrote the paper: AKM AAA.

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Mouse models
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NK cells
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Spleen
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Lymph nodes
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Cancers and neoplasms
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Cell staining
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Thymus
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Malignant tumors
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