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Research Article

Opposite Effects of Low and High Doses of Aβ42 on Electrical Network and Neuronal Excitability in the Rat Prefrontal Cortex

  • Yun Wang mail,

    yun.wang@tufts.edu

    Affiliation: Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

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  • Guangping Zhang,

    Affiliation: Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

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  • Hongwei Zhou,

    Affiliation: Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

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  • Amey Barakat,

    Affiliation: Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

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  • Henry Querfurth

    Affiliation: Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

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  • Published: December 21, 2009
  • DOI: 10.1371/journal.pone.0008366

About the Authors

Yun Wang, Guangping Zhang, Hongwei Zhou, Amey Barakat, Henry Querfurth
Neurology Research, Caritas St. Elizabeth's Medical Center, Tufts Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: yun.wang@tufts.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YW. Performed the experiments: YW GZ HZ AB. Analyzed the data: YW GZ. Contributed reagents/materials/analysis tools: YW. Wrote the paper: YW HQ. Provided expertise in AD research and edited the manuscript: HQ.