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Research Article

Next-Generation Phage Display: Integrating and Comparing Available Molecular Tools to Enable Cost-Effective High-Throughput Analysis

  • Emmanuel Dias-Neto,

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

    Current address: Centro de Pesquisas, Hospital A. C. Camargo. São Paulo, São Paulo, Brazil

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  • Diana N. Nunes,

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Ricardo J. Giordano,

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Jessica Sun,

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Gregory H. Botz,

    Affiliation: Department of Critical Care, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Kuan Yang,

    Affiliation: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • João C. Setubal,

    Affiliations: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America, Computer Science Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

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  • Renata Pasqualini mail,

    rpasqual@mdanderson.org (RP); warap@mdanderson.org (WA)

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Wadih Arap mail

    rpasqual@mdanderson.org (RP); warap@mdanderson.org (WA)

    Affiliation: David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Published: December 17, 2009
  • DOI: 10.1371/journal.pone.0008338

About the Authors

Emmanuel Dias-Neto, Diana N. Nunes, Ricardo J. Giordano, Jessica Sun, Renata Pasqualini, Wadih Arap
David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Gregory H. Botz
Department of Critical Care, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Kuan Yang, João C. Setubal
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
João C. Setubal
Computer Science Department, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EDN DNN RG RP. Performed the experiments: EDN DNN RG. Analyzed the data: EDN DNN RG JS KY JCS RP WA. Contributed reagents/materials/analysis tools: EDN DNN RG JS GHB KY JCS RP WA. Wrote the paper: EDN DNN RG JCS RP WA.