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Research Article

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

  • Kanae Iijima-Ando mail,

    Kanae.Iijima-Ando@jefferson.edu (KIA); Koichi.Iijima@jefferson.edu (KI)

    Affiliation: Laboratory of Neurogenetics and Pathobiology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Stephen A. Hearn,

    Affiliation: Microscopy Facility, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Christopher Shenton,

    Affiliations: Laboratory of Neurogenetics and Pathobiology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Biochemistry and Molecular Biology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Anthony Gatt,

    Affiliation: Department of Biochemistry and Molecular Biology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • LiJuan Zhao,

    Affiliation: Laboratory of Neurogenetics and Pathobiology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Koichi Iijima mail

    Kanae.Iijima-Ando@jefferson.edu (KIA); Koichi.Iijima@jefferson.edu (KI)

    Affiliation: Department of Biochemistry and Molecular Biology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: December 15, 2009
  • DOI: 10.1371/journal.pone.0008310

About the Authors

Kanae Iijima-Ando, Christopher Shenton, LiJuan Zhao
Laboratory of Neurogenetics and Pathobiology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Christopher Shenton, Anthony Gatt, Koichi Iijima
Department of Biochemistry and Molecular Biology, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Stephen A. Hearn
Microscopy Facility, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KIA KI. Performed the experiments: KIA SAH CS AG LZ KI. Analyzed the data: KIA SAH KI. Contributed reagents/materials/analysis tools: KIA KI. Wrote the paper: KIA KI.