About the Authors

Dale Hedges

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Dan Burges

Affiliation Roche Diagnostics Corporation Inc., Indianapolis, Indiana, United States of America

Eric Powell

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Cherylyn Almonte

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Jia Huang

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Stuart Young

Affiliation Center for Computational Sciences, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Benjamin Boese

Affiliation Roche Diagnostics Corporation Inc., Indianapolis, Indiana, United States of America

Mike Schmidt

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Margaret A. Pericak-Vance

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Eden Martin

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Xinmin Zhang

Affiliation Roche Diagnostics Corporation Inc., Indianapolis, Indiana, United States of America

Timothy T. Harkins

Affiliation Roche Diagnostics Corporation Inc., Indianapolis, Indiana, United States of America

Stephan Züchner

szuchner@med.miami.edu

Affiliation John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Competing Interests

Roche provided complementary reagents and services for conducting some components of this study. The academic members of this study have no conflicting financial interests to declare, such as consulting fees, employment with a commercial partner, or similar. The manuscript was prepared solely under the direction of the academic authors. They adhere to all PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors http://www.plosone.org/static/policies.action#sharing. Authors Benjamin Boese, Xinmin Zhang, and Timothy Harkins are employed by Roche, Inc., which develops and sells next generation sequencing and genome capture technology.

Author Contributions

Conceived and designed the experiments: DJH SZ. Performed the experiments: JH XZ TH. Analyzed the data: DJH EP CA SY MS EM SZ. Contributed reagents/materials/analysis tools: DB BB MAPV XZ TH. Wrote the paper: DJH EM SZ.