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Research Article

Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat

  • Amanda-Jayne Carr equal contributor mail,

    equal contributor Contributed equally to this work with: Amanda-Jayne Carr, Anthony A. Vugler, Sherry T. Hikita, Jean M. Lawrence

    a.carr@ucl.ac.uk

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Anthony A. Vugler equal contributor,

    equal contributor Contributed equally to this work with: Amanda-Jayne Carr, Anthony A. Vugler, Sherry T. Hikita, Jean M. Lawrence

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Sherry T. Hikita equal contributor,

    equal contributor Contributed equally to this work with: Amanda-Jayne Carr, Anthony A. Vugler, Sherry T. Hikita, Jean M. Lawrence

    Affiliation: Center for Stem Cell Biology and Engineering, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Jean M. Lawrence equal contributor,

    equal contributor Contributed equally to this work with: Amanda-Jayne Carr, Anthony A. Vugler, Sherry T. Hikita, Jean M. Lawrence

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Carlos Gias,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Li Li Chen,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • David E. Buchholz,

    Affiliation: Center for Stem Cell Biology and Engineering, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Ahmad Ahmado,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Ma'ayan Semo,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Matthew J. K. Smart,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Shazeen Hasan,

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Lyndon da Cruz,

    Affiliation: Department of Vitreoretinal Surgery, Moorfields Eye Hospital, London, United Kingdom

    X
  • Lincoln V. Johnson,

    Affiliations: Center for Stem Cell Biology and Engineering, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America, Center for the Study of Macular Degeneration, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Dennis O. Clegg,

    Affiliations: Center for Stem Cell Biology and Engineering, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America, Center for the Study of Macular Degeneration, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Pete J. Coffey

    Affiliation: Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom

    X
  • Published: December 03, 2009
  • DOI: 10.1371/journal.pone.0008152

About the Authors

Amanda-Jayne Carr, Anthony A. Vugler, Jean M. Lawrence, Carlos Gias, Li Li Chen, Ahmad Ahmado, Ma'ayan Semo, Matthew J. K. Smart, Shazeen Hasan, Pete J. Coffey
Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
Sherry T. Hikita, David E. Buchholz, Lincoln V. Johnson, Dennis O. Clegg
Center for Stem Cell Biology and Engineering, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America
Lincoln V. Johnson, Dennis O. Clegg
Center for the Study of Macular Degeneration, University of California Santa Barbara, Santa Barbara, California, United States of America
Lyndon da Cruz
Department of Vitreoretinal Surgery, Moorfields Eye Hospital, London, United Kingdom

Corresponding Author

Email: a.carr@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJFC AV STH JML LdC LJ DC PC. Performed the experiments: AJFC AV STH JML CG LLC DEB AA MJKS SH. Analyzed the data: AJFC AV STH JML CG DEB MS DC. Contributed reagents/materials/analysis tools: AJFC AV STH JML DEB PC. Wrote the paper: AJFC AV JML.