PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

Sounak Gupta; Barbara McGrath; Douglas R. Cavener

doi:10.1371/journal.pone.0008008

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Open Access

Peer-reviewed

Research Article

PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

Sounak Gupta,

Affiliations Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Barbara McGrath,

Affiliation Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Douglas R. Cavener

* E-mail: drc9@psu.edu

Affiliations Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯

PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

Sounak Gupta,
Barbara McGrath,
Douglas R. Cavener

Published: November 24, 2009
https://doi.org/10.1371/journal.pone.0008008

About the Authors

Sounak Gupta

Affiliations Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America

Barbara McGrath

Affiliation Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

Douglas R. Cavener

* E-mail: drc9@psu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SG BM DRC. Performed the experiments: SG DRC. Analyzed the data: SG BM DRC. Contributed reagents/materials/analysis tools: DRC. Wrote the paper: SG BM DRC.

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Insulinoma
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Cancers and neoplasms
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Colorectal cancer
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Angiogenesis
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Diabetes mellitus
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Hypoxia
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Insulin
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Pancreas
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