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Research Article

A Predictive Phosphorylation Signature of Lung Cancer

  • Chang-Jiun Wu,

    Affiliation: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

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  • Tianxi Cai,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Klarisa Rikova,

    Affiliation: Cell Signaling Technology, Danvers, Massachusetts, United States of America

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  • David Merberg,

    Affiliation: Vertex Pharmaceuticals, Cambridge, Massachusetts, United States of America

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  • Simon Kasif equal contributor,

    equal contributor Contributed equally to this work with: Simon Kasif, Martin Steffen

    Affiliations: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, United States of America, Center for Advanced Genomic Technology, Boston University, Boston, Massachusetts, United States of America

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  • Martin Steffen equal contributor mail

    equal contributor Contributed equally to this work with: Simon Kasif, Martin Steffen

    steffen@bu.edu

    Affiliations: Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Published: November 25, 2009
  • DOI: 10.1371/journal.pone.0007994

About the Authors

Chang-Jiun Wu, Simon Kasif, Martin Steffen
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
Tianxi Cai
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Klarisa Rikova
Cell Signaling Technology, Danvers, Massachusetts, United States of America
David Merberg
Vertex Pharmaceuticals, Cambridge, Massachusetts, United States of America
Simon Kasif
Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, United States of America
Simon Kasif
Center for Advanced Genomic Technology, Boston University, Boston, Massachusetts, United States of America
Martin Steffen
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Corresponding Author

Email: steffen@bu.edu

Competing Interests

D.M. and K.R. are employees of Vertex Pharmaceuticals and Cell Signaling Technology, respectively. Neither company provided any direct funds for this manuscript or had any role in the analysis, decision to publish, or preparation of the manuscript. These relationships do not alter the authors' adherence to all PLoS ONE policies on sharing data and materials as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SK MS. Performed the experiments: CJW KR. Analyzed the data: CJW TC KR DM SK MS. Wrote the paper: CJW SK MS.