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Research Article

Novel Protein-Protein Interactions Inferred from Literature Context

  • Herman H. H. B. M. van Haagen mail,

    hvanhaagen@lumc.nl

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Peter A. C. 't Hoen,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Alessandro Botelho Bovo,

    Affiliation: Post-Graduate Program in Knowledge Engineering and Management (EGC), Federal University of Santa Catarina (UFSC), Florianópolis, Brazil

    X
  • Antoine de Morrée,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Erik M. van Mulligen,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Christine Chichester,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Jan A. Kors,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Johan T. den Dunnen,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Gert-Jan B. van Ommen,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Silvère M. van der Maarel,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Vinícius Medina Kern,

    Affiliation: Post-Graduate Program in Knowledge Engineering and Management (EGC), Federal University of Santa Catarina (UFSC), Florianópolis, Brazil

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  • Barend Mons,

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Martijn J. Schuemie

    Affiliation: Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Published: November 18, 2009
  • DOI: 10.1371/journal.pone.0007894

About the Authors

Herman H. H. B. M. van Haagen, Peter A. C. 't Hoen, Antoine de Morrée, Erik M. van Mulligen, Christine Chichester, Jan A. Kors, Johan T. den Dunnen, Gert-Jan B. van Ommen, Silvère M. van der Maarel, Barend Mons, Martijn J. Schuemie
Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Alessandro Botelho Bovo, Vinícius Medina Kern
Post-Graduate Program in Knowledge Engineering and Management (EGC), Federal University of Santa Catarina (UFSC), Florianópolis, Brazil

Corresponding Author

Email: hvanhaagen@lumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HHHBMvH ABB. Performed the experiments: HHHBMvH AdM. Analyzed the data: HHHBMvH PACH ABB EMvM CC JAK BM MJS. Contributed reagents/materials/analysis tools: HHHBMvH ABB BM. Wrote the paper: HHHBMvH PACH ABB AdM BM MJS. Corrected manuscript: EMvM CC JAK JTdD GBvO SMvM. Supervised HvH: PACtH JTdD GBvO BM. Main supervisor for HvH: MJS. Supervised AdM: SMvM. Supervised ABB: VMK.