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Research Article

Serum S100A6 Concentration Predicts Peritoneal Tumor Burden in Mice with Epithelial Ovarian Cancer and Is Associated with Advanced Stage in Patients

  • Bih-Rong Wei,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Shelley B. Hoover,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Mark M. Ross,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Weidong Zhou,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Francesco Meani,

    Affiliation: University of Brescia, Brescia, Italy

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  • Jennifer B. Edwards,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Elizabeth I. Spehalski,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    Current address: Department of Molecular and Cellular Pathology, University of Michigan College of Medicine, Ann Arbor, Michigan, United States of America

    X
  • John I. Risinger,

    Affiliation: Anderson Cancer Institute, Memorial Health University Medical Center, Inc., Savannah, Georgia, United States of America

    Current address: Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, Michigan, United States of America

    X
  • W. Gregory Alvord,

    Affiliation: Data Management Services, Inc., National Cancer Institute, Frederick, Maryland, United States of America

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  • Octavio A. Quiñones,

    Affiliation: Data Management Services, Inc., National Cancer Institute, Frederick, Maryland, United States of America

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  • Claudio Belluco,

    Affiliations: Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy, Department of Haematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy

    X
  • Luca Martella,

    Affiliation: Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy

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  • Elio Campagnutta,

    Affiliation: Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy

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  • Antonella Ravaggi,

    Affiliation: University of Brescia, Brescia, Italy

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  • Ren-Ming Dai,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    Current address: Laboratory of Experimental Immunology, NCI Frederick, Frederick, Maryland, United States of America

    X
  • Paul K. Goldsmith,

    Affiliation: Antibody and Protein Purification Unit, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Kevin D. Woolard,

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    Current address: Neuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland, United States of America

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  • Sergio Pecorelli,

    Affiliation: University of Brescia, Brescia, Italy

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  • Lance A. Liotta,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Emanuel F. Petricoin III,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • R. Mark Simpson mail

    ms43b@nih.gov

    Affiliation: Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

    X
  • Published: October 30, 2009
  • DOI: 10.1371/journal.pone.0007670

About the Authors

Bih-Rong Wei, Shelley B. Hoover, Jennifer B. Edwards, Elizabeth I. Spehalski, Ren-Ming Dai, Kevin D. Woolard, R. Mark Simpson
Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
Mark M. Ross, Weidong Zhou, Lance A. Liotta, Emanuel F. Petricoin III
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America
Francesco Meani, Antonella Ravaggi, Sergio Pecorelli
University of Brescia, Brescia, Italy
John I. Risinger
Anderson Cancer Institute, Memorial Health University Medical Center, Inc., Savannah, Georgia, United States of America
W. Gregory Alvord, Octavio A. Quiñones
Data Management Services, Inc., National Cancer Institute, Frederick, Maryland, United States of America
Claudio Belluco, Luca Martella, Elio Campagnutta
Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
Paul K. Goldsmith
Antibody and Protein Purification Unit, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
Claudio Belluco
Department of Haematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy

Corresponding Author

Email: ms43b@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BRW SBH MMR WZ FM JIR WGA OAQ CB PKG SP LL EPI RMS. Performed the experiments: BRW SBH MMR WZ FM JBE ES JIR WGA OAQ CB LM EC RMD RMS. Analyzed the data: BRW SBH MMR WZ FM JBE ES JIR WGA OAQ RMD KDW LL EPI RMS. Contributed reagents/materials/analysis tools: FM CB LM EC PKG SP. Wrote the paper: BRW SBH MMR FM JIR WGA KDW LL EPI RMS. Revising and final approval: RMS BRW SBH MMR WZ FM JBE ES JIR WGA OAQ CB LM EC AR RMD PKG KDW SP LL EP.