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Research Article

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography

  • M. Dominik Fischer equal contributor,

    equal contributor Contributed equally to this work with: M. Dominik Fischer, Gesine Huber

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Gesine Huber equal contributor,

    equal contributor Contributed equally to this work with: M. Dominik Fischer, Gesine Huber

    Affiliations: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany, Institute of Animal Welfare, Ethology and Animal Hygiene, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany

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  • Susanne C. Beck,

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Naoyuki Tanimoto,

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Regine Muehlfriedel,

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Edda Fahl,

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Christian Grimm,

    Affiliation: Laboratory of Retinal Cell Biology, University of Zurich, Zurich, Switzerland

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  • Andreas Wenzel,

    Affiliation: Laboratory of Retinal Cell Biology, University of Zurich, Zurich, Switzerland

    Current address: Novartis Pharma Schweiz AG, Berne, Switzerland

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  • Charlotte E. Remé,

    Affiliation: Laboratory of Retinal Cell Biology, University of Zurich, Zurich, Switzerland

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  • Serge A. van de Pavert,

    Affiliation: Neuromedical Genetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

    Current address: VU University Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands

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  • Jan Wijnholds,

    Affiliation: Neuromedical Genetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Marek Pacal,

    Affiliation: Toronto Western Research Institute, University Health Network, Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Rod Bremner,

    Affiliation: Toronto Western Research Institute, University Health Network, Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Mathias W. Seeliger mail

    see@uni-tuebingen.de

    Affiliation: Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany

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  • Published: October 19, 2009
  • DOI: 10.1371/journal.pone.0007507

About the Authors

M. Dominik Fischer, Gesine Huber, Susanne C. Beck, Naoyuki Tanimoto, Regine Muehlfriedel, Edda Fahl, Mathias W. Seeliger
Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
Gesine Huber
Institute of Animal Welfare, Ethology and Animal Hygiene, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany
Christian Grimm, Andreas Wenzel, Charlotte E. Remé
Laboratory of Retinal Cell Biology, University of Zurich, Zurich, Switzerland
Serge A. van de Pavert, Jan Wijnholds
Neuromedical Genetics, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
Marek Pacal, Rod Bremner
Toronto Western Research Institute, University Health Network, Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: see@uni-tuebingen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MDF MWS. Performed the experiments: MDF GH SB NT RM EF CG AW CER SAvdP JW MWS. Analyzed the data: MDF GH SB NT RM EF CG AW CER SAvdP JW MP RB MWS. Contributed reagents/materials/analysis tools: MDF GH SB NT RM EF CG AW CER SAvdP JW MP RB MWS. Wrote the paper: MWS. Edited the manuscript: CG AW CER SAvdP JW MP RB.