About the Authors

Atsushi Oyagi

Affiliation Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

Yasuhisa Oida

Affiliation Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

Kenichi Kakefuda

Affiliation Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

Masamitsu Shimazawa

Affiliation Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

Norifumi Shioda

Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

Shigeki Moriguchi

Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

Kiyoyuki Kitaichi

Affiliation Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan

Daisuke Nanba

Affiliation Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan

Kazumasa Yamaguchi

Affiliation Nihon Bioresearch Center Inc., Gifu, Japan

Yasuhide Furuta

Affiliation Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Kohji Fukunaga

Affiliation Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

Shigeki Higashiyama

Affiliation Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan

Hideaki Hara

hidehara@gifu-pu.ac.jp

Affiliation Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

Competing Interests

K. Yamaguchi is an employee of Nihon Bioresearch Center Inc. The other authors declare no competing interests exist.

Author Contributions

Conceived and designed the experiments: AO MS HH. Performed the experiments: AO YO KK NS SM KK DN KY KF. Contributed reagents/materials/analysis tools: YF SH. Wrote the paper: AO.