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Research Article

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

  • Gerold Schmitt-Ulms mail,

    g.schmittulms@utoronto.ca

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Sepehr Ehsani,

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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  • Joel C. Watts,

    Affiliations: Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, United States of America

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  • David Westaway,

    Affiliation: Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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  • Holger Wille

    Affiliations: Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, United States of America, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

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  • Published: September 28, 2009
  • DOI: 10.1371/journal.pone.0007208

About the Authors

Gerold Schmitt-Ulms, Sepehr Ehsani, Joel C. Watts
Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
Gerold Schmitt-Ulms, Sepehr Ehsani, Joel C. Watts
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Joel C. Watts, Holger Wille
Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, California, United States of America
Holger Wille
Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
David Westaway
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: g.schmittulms@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GSU. Performed the experiments: GSU SE JCW HW. Analyzed the data: GSU SE JCW DW HW. Contributed reagents/materials/analysis tools: GSU DW. Wrote the paper: GSU SE JCW DW HW.