Advertisement
Research Article

Cell Cycle Re-Entry and Mitochondrial Defects in Myc-Mediated Hypertrophic Cardiomyopathy and Heart Failure

  • Hyoung-gon Lee mail,

    hyoung-gon.lee@case.edu (HgL); mark.smith@case.edu (MAS)

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Qun Chen,

    Affiliation: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Julie A. Wolfram,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Sandy L. Richardson,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Anna Liner,

    Affiliations: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America

    X
  • Sandra L. Siedlak,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Xiongwei Zhu,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Nicholas P. Ziats,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Hisashi Fujioka,

    Affiliation: Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Dean W. Felsher,

    Affiliation: Division of Oncology, Department of Medicine and Pathology, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Rudy J. Castellani,

    Affiliation: Department of Pathology, University of Maryland, Baltimore, Maryland, United States of America

    X
  • Maria L. Valencik,

    Affiliation: Department of Biochemistry, University of Nevada Reno, Reno, Nevada, United States of America

    X
  • John A. McDonald,

    Affiliation: Department of Biochemistry, University of Nevada Reno, Reno, Nevada, United States of America

    X
  • Brian D. Hoit,

    Affiliations: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America

    X
  • Edward J. Lesnefsky,

    Affiliations: Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Louis Stokes Cleveland DVAMC, Cleveland, Ohio, United States of America

    Current address: Department of Medicine, Division of Cardiology, Virginia Commonwealth University, and McGuire DVAMC, Richmond, Virginia, United States of America

    X
  • Mark A. Smith mail

    hyoung-gon.lee@case.edu (HgL); mark.smith@case.edu (MAS)

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Published: September 25, 2009
  • DOI: 10.1371/journal.pone.0007172

About the Authors

Hyoung-gon Lee, Julie A. Wolfram, Sandy L. Richardson, Sandra L. Siedlak, Xiongwei Zhu, Nicholas P. Ziats, Mark A. Smith
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
Qun Chen, Anna Liner, Brian D. Hoit, Edward J. Lesnefsky
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
Hisashi Fujioka
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, United States of America
Edward J. Lesnefsky
Louis Stokes Cleveland DVAMC, Cleveland, Ohio, United States of America
Anna Liner, Brian D. Hoit
University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
Dean W. Felsher
Division of Oncology, Department of Medicine and Pathology, Stanford University School of Medicine, Stanford, California, United States of America
Rudy J. Castellani
Department of Pathology, University of Maryland, Baltimore, Maryland, United States of America
Maria L. Valencik, John A. McDonald
Department of Biochemistry, University of Nevada Reno, Reno, Nevada, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAS. Performed the experiments: HgL QC SLR AL SLS HF BDH EJL. Analyzed the data: HgL JAW AL SLS XZ NPZ HF DWF RJC MLV JAM BDH EJL MAS. Contributed reagents/materials/analysis tools: DWF. Wrote the paper: HgL SLS BDH EJL MAS.