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Research Article

Enterocyte Shedding and Epithelial Lining Repair Following Ischemia of the Human Small Intestine Attenuate Inflammation

  • Robert A. Matthijsen,

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

    Current address: Spaarne Hospital, Hoofddorp, the Netherlands

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  • Joep P. M. Derikx,

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

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  • Dian Kuipers,

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

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  • Ronald M. van Dam,

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

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  • Cornelis H. C. Dejong,

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

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  • Wim A. Buurman mail

    w.buurman@ah.unimaas.nl

    Affiliation: Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

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  • Published: September 15, 2009
  • DOI: 10.1371/journal.pone.0007045

About the Authors

Robert A. Matthijsen, Joep P. M. Derikx, Dian Kuipers, Ronald M. van Dam, Cornelis H. C. Dejong, Wim A. Buurman
Department of Surgery, School for Nutrition & Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, the Netherlands

Corresponding Author

Email: w.buurman@ah.unimaas.nl

Competing Interests

W.A. Buurman is shareholder of the company Hycult Biotechnology (Hbt, Uden, the Netherlands) which provided the human MBL and I-FABP ELISAs. These ELISAs, as used, are commercially available worldwide.

Author Contributions

Conceived and designed the experiments: RM JD DK RvD CD WB. Performed the experiments: RM JD DK RvD WB. Analyzed the data: RM JD DK RvD CD WB. Contributed reagents/materials/analysis tools: RM JD DK CD WB. Wrote the paper: RM JD RvD CD.