About the Authors

Richard A. Klinghoffer

richard_klinghoffer@merck.com

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

Jason Frazier

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

James Annis

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

Jason D. Berndt

Affiliation Howard Hughes Medical Institute, Institute for Stem Cell and Regenerative Medicine, and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington, United States of America

Brian S. Roberts

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

William T. Arthur

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

Raul Lacson

Affiliation Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc., North Wales, Pennsylvania, United States of America

Xiaohua Douglas Zhang

Affiliation Department of Biometrics Research, Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania, United States of America

Marc Ferrer

Affiliation Department of Automated Biotechnology, Merck Research Laboratories, Merck & Co., Inc., North Wales, Pennsylvania, United States of America

Randall T. Moon

Affiliation Howard Hughes Medical Institute, Institute for Stem Cell and Regenerative Medicine, and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington, United States of America

Michele A. Cleary

Affiliation Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America

Competing Interests

RK, JF, JA, BR, WA, RL, XZ, MF and MC are all employees of the commercial company that funded this study (Merck).

Author Contributions

Conceived and designed the experiments: RAK JF JDB BSR WTA RM MC. Performed the experiments: RAK JF JA JDB BSR RL. Analyzed the data: RAK JF JA JDB BSR XDZ MF. Contributed reagents/materials/analysis tools: RM. Wrote the paper: RAK MC.