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Research Article

Butyrate-Induced Transcriptional Changes in Human Colonic Mucosa

  • Steven A. L. W. Vanhoutvin mail,

    s.vanhoutvin@intmed.unimaas.nl

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Freddy J. Troost,

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Henrike M. Hamer,

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Patrick J. Lindsey,

    Affiliation: Department of Population Genetics, Genomics and Bioinformatics, Maastricht University, Maastricht, The Netherlands

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  • Ger H. Koek,

    Affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Daisy M. A. E. Jonkers,

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Andrea Kodde,

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands

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  • Koen Venema,

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Department of Bio Sciences, TNO Quality of life, Zeist, The Netherlands

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  • Robert J. M. Brummer

    Affiliations: TI Food and Nutrition, Wageningen, The Netherlands, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands, School of Health and Medical Sciences, Örebro University, Örebro, Sweden

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  • Published: August 25, 2009
  • DOI: 10.1371/journal.pone.0006759

About the Authors

Steven A. L. W. Vanhoutvin, Freddy J. Troost, Henrike M. Hamer, Daisy M. A. E. Jonkers, Andrea Kodde, Koen Venema, Robert J. M. Brummer
TI Food and Nutrition, Wageningen, The Netherlands
Steven A. L. W. Vanhoutvin, Freddy J. Troost, Henrike M. Hamer, Ger H. Koek, Daisy M. A. E. Jonkers, Andrea Kodde, Robert J. M. Brummer
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University, Maastricht, The Netherlands
Patrick J. Lindsey
Department of Population Genetics, Genomics and Bioinformatics, Maastricht University, Maastricht, The Netherlands
Koen Venema
Department of Bio Sciences, TNO Quality of life, Zeist, The Netherlands
Robert J. M. Brummer
School of Health and Medical Sciences, Örebro University, Örebro, Sweden

Corresponding Author

Email: s.vanhoutvin@intmed.unimaas.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SALWV FT HMH GHK DMAEJ AK KV RJB. Performed the experiments: SALWV HMH GHK RJB. Analyzed the data: PL. Contributed reagents/materials/analysis tools: AK. Wrote the paper: SALWV FT. Made significant corrections to the manuscript: FT PL DMAEJ KV.