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Research Article

Comparative Analysis of Pyrosequencing and a Phylogenetic Microarray for Exploring Microbial Community Structures in the Human Distal Intestine

  • Marcus J. Claesson mail,

    mclaesson@bioinfo.ucc.ie

    Affiliations: Department of Microbiology, University College Cork, Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Orla O'Sullivan,

    Affiliation: Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland

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  • Qiong Wang,

    Affiliation: Center for Microbial Ecology and Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

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  • Janne Nikkilä,

    Affiliation: Department of Basic Veterinary Medicine, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland

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  • Julian R. Marchesi,

    Affiliations: Department of Microbiology, University College Cork, Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

    Current address: Cardiff School of Biosciences, Cardiff, United Kingdom

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  • Hauke Smidt,

    Affiliation: Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

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  • Willem M. de Vos,

    Affiliations: Department of Basic Veterinary Medicine, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland, Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

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  • R. Paul Ross,

    Affiliations: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland, Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland

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  • Paul W. O'Toole

    Affiliations: Department of Microbiology, University College Cork, Cork, Ireland, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

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  • Published: August 20, 2009
  • DOI: 10.1371/journal.pone.0006669

About the Authors

Marcus J. Claesson, Julian R. Marchesi, Paul W. O'Toole
Department of Microbiology, University College Cork, Cork, Ireland
Marcus J. Claesson, Julian R. Marchesi, R. Paul Ross, Paul W. O'Toole
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Orla O'Sullivan, R. Paul Ross
Teagasc, Moorepark Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland
Qiong Wang
Center for Microbial Ecology and Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America
Janne Nikkilä, Willem M. de Vos
Department of Basic Veterinary Medicine, Division of Microbiology and Epidemiology, University of Helsinki, Helsinki, Finland
Hauke Smidt, Willem M. de Vos
Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands

Corresponding Author

Email: mclaesson@bioinfo.ucc.ie

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJC JRM PWO. Performed the experiments: MJC OO QW JN. Analyzed the data: MJC OO QW JN HS WMdV. Contributed reagents/materials/analysis tools: QW JRM HS WMdV RPR. Wrote the paper: MJC OO PWO.