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Research Article

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

  • Adolfo Sequeira,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

    Current address: Department of Psychiatry and Human Behavior at University of California Irvine, Irvine, California, United States of America

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  • Firoza Mamdani,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Carl Ernst,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Marquis P. Vawter,

    Affiliation: Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, California, United States of America

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  • William E. Bunney,

    Affiliation: Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, California, United States of America

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  • Veronique Lebel,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Sonia Rehal,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Tim Klempan,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Alain Gratton,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Chawki Benkelfat,

    Affiliation: Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada

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  • Guy A. Rouleau,

    Affiliation: Ste Justine Hospital, Université de Montréal, Montreal, Quebec, Canada

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  • Naguib Mechawar,

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Gustavo Turecki mail

    gustavo.turecki@mcgill.ca

    Affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

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  • Published: August 11, 2009
  • DOI: 10.1371/journal.pone.0006585

About the Authors

Adolfo Sequeira, Firoza Mamdani, Carl Ernst, Veronique Lebel, Sonia Rehal, Tim Klempan, Alain Gratton, Naguib Mechawar, Gustavo Turecki
McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
Chawki Benkelfat
Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
Guy A. Rouleau
Ste Justine Hospital, Université de Montréal, Montreal, Quebec, Canada
Marquis P. Vawter, William E. Bunney
Department of Psychiatry and Human Behavior, School of Medicine, University of California Irvine, Irvine, California, United States of America

Corresponding Author

Email: gustavo.turecki@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS FM GT. Performed the experiments: AS FM CE MV WEB VLL SR GT. Analyzed the data: AS FM CE MV WEB VLL SR TAK AG GAR. Contributed reagents/materials/analysis tools: CE MV WEB TAK CB GAR NM. Wrote the paper: AS FM GT.