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Research Article

Community Analysis of Chronic Wound Bacteria Using 16S rRNA Gene-Based Pyrosequencing: Impact of Diabetes and Antibiotics on Chronic Wound Microbiota

  • Lance B. Price mail,

    lprice@tgen.org

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Cindy M. Liu,

    Affiliations: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America, Northern Arizona University, Flagstaff, Arizona, United States of America

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  • Johan H. Melendez,

    Affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Yelena M. Frankel,

    Affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • David Engelthaler,

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Maliha Aziz,

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Jolene Bowers,

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Rogan Rattray,

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Jacques Ravel,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Chris Kingsley,

    Affiliation: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America

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  • Paul S. Keim,

    Affiliations: Translational Genomics Research Institute, Flagstaff, Arizona, United States of America, Northern Arizona University, Flagstaff, Arizona, United States of America

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  • Gerald S. Lazarus,

    Affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Jonathan M. Zenilman

    Affiliation: Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Published: July 31, 2009
  • DOI: 10.1371/journal.pone.0006462

About the Authors

Lance B. Price, Cindy M. Liu, David Engelthaler, Maliha Aziz, Jolene Bowers, Rogan Rattray, Chris Kingsley, Paul S. Keim
Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
Cindy M. Liu, Paul S. Keim
Northern Arizona University, Flagstaff, Arizona, United States of America
Johan H. Melendez, Yelena M. Frankel, Gerald S. Lazarus, Jonathan M. Zenilman
Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Jacques Ravel
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: lprice@tgen.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LBP CML JHM YMF DME JRB PK GL JZ. Performed the experiments: CML JHM YMF JRB RR JR. Analyzed the data: LBP CML JHM YMF DME MA JRB RR CK PK GL JZ. Contributed reagents/materials/analysis tools: LBP DME MA JR CK PK GL JZ. Wrote the paper: LBP CML PK JZ. Edited the manuscript: JHM YMF DME. Contributed text to the final manuscript: MA JRB RR JR CK. Performed statistical analysis: CK. Critically reviewed the manuscript: GL.