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Research Article

Signal Regulatory Protein α (SIRPα)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria

  • W. Ray Waters mail,

    ray.waters@ars.usda.gov

    Affiliation: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America

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  • Mitchell V. Palmer,

    Affiliation: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America

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  • Brian J. Nonnecke,

    Affiliation: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America

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  • Tyler C. Thacker,

    Affiliation: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America

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  • D. Mark Estes,

    Affiliation: University of Texas Medical Branch, Department of Pediatrics and the Sealy Center for Vaccine Development, Galveston, Texas, United States of America

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  • Michelle H. Larsen,

    Affiliation: Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • William R. Jacobs Jr,

    Affiliation: Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Peter Andersen,

    Affiliation: Statens Serum Institute, Copenhagen, Denmark

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  • James McNair,

    Affiliation: Bacteriology Department, Veterinary Sciences Division, Stormont, Belfast

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  • F. C. Minion,

    Affiliation: Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, United States of America

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  • Konstantin P. Lyashchenko,

    Affiliation: Chembio Diagnostic Systems, Medford, New York, United States of America

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  • R. Glyn Hewinson,

    Affiliation: UK Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom

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  • H. Martin Vordermeier,

    Affiliation: UK Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom

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  • Randy E. Sacco

    Affiliation: National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America

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  • Published: July 29, 2009
  • DOI: 10.1371/journal.pone.0006414

About the Authors

W. Ray Waters, Mitchell V. Palmer, Brian J. Nonnecke, Tyler C. Thacker, Randy E. Sacco
National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa, United States of America
D. Mark Estes
University of Texas Medical Branch, Department of Pediatrics and the Sealy Center for Vaccine Development, Galveston, Texas, United States of America
Michelle H. Larsen, William R. Jacobs Jr
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
Peter Andersen
Statens Serum Institute, Copenhagen, Denmark
James McNair
Bacteriology Department, Veterinary Sciences Division, Stormont, Belfast
F. C. Minion
Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, United States of America
Konstantin P. Lyashchenko
Chembio Diagnostic Systems, Medford, New York, United States of America
R. Glyn Hewinson, H. Martin Vordermeier
UK Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom

Corresponding Author

Email: ray.waters@ars.usda.gov

Competing Interests

Peter Andersen is co-inventor of patents relating to TB antigens, ESAT-6 and CFP-10. All rights have been assigned to Statens Serum Institut.

Author Contributions

Conceived and designed the experiments: WRW MVP BJN TCT DME RES. Performed the experiments: WRW MVP TCT MHL WRJ RES. Analyzed the data: WRW MVP BJN RES. Contributed reagents/materials/analysis tools: WRW MVP BJN DME MHL WRJ PA JM CM KL GH MV RES. Wrote the paper: WRW DME RES.