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Research Article

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

  • Satheesh K. Palaninathan equal contributor,

    equal contributor Contributed equally to this work with: Satheesh K. Palaninathan, Nilofar N. Mohamedmohaideen

    Affiliation: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

    X
  • Nilofar N. Mohamedmohaideen equal contributor,

    equal contributor Contributed equally to this work with: Satheesh K. Palaninathan, Nilofar N. Mohamedmohaideen

    Affiliation: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

    X
  • Elisabetta Orlandini mail,

    eorlandini@farm.unipi.it (EO); sacchett@tamu.edu (JCS)

    Affiliation: Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

    X
  • Gabriella Ortore,

    Affiliation: Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

    X
  • Susanna Nencetti,

    Affiliation: Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

    X
  • Annalina Lapucci,

    Affiliation: Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

    X
  • Armando Rossello,

    Affiliation: Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

    X
  • Joel S. Freundlich,

    Affiliation: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

    X
  • James C. Sacchettini mail

    eorlandini@farm.unipi.it (EO); sacchett@tamu.edu (JCS)

    Affiliation: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

    X
  • Published: July 21, 2009
  • DOI: 10.1371/journal.pone.0006290

About the Authors

Satheesh K. Palaninathan, Nilofar N. Mohamedmohaideen, Joel S. Freundlich, James C. Sacchettini
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America
Elisabetta Orlandini, Gabriella Ortore, Susanna Nencetti, Annalina Lapucci, Armando Rossello
Dipartimento di Scienze Farmaceutiche, Università Pisa, Pisa, Italy

Corresponding Authors

Competing Interests

N/A

Author Contributions

Conceived and designed the experiments: SP NNM EO JCS. Performed the experiments: SP NNM EO GO SN AL AR. Analyzed the data: SP NNM EO GO AR JSF JCS. Wrote the paper: SP NNM EO JSF JCS.