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Research Article

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6

  • Lorna S. Kategaya equal contributor,

    equal contributor Contributed equally to this work with: Lorna S. Kategaya, Binita Changkakoty, Travis Biechele

    Affiliation: Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Binita Changkakoty equal contributor,

    equal contributor Contributed equally to this work with: Lorna S. Kategaya, Binita Changkakoty, Travis Biechele

    Affiliation: Department of Pharmacology and Cancer Institute, New York University School of Medicine, New York, New York, United States of America

    X
  • Travis Biechele equal contributor,

    equal contributor Contributed equally to this work with: Lorna S. Kategaya, Binita Changkakoty, Travis Biechele

    Affiliation: Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • William H. Conrad,

    Affiliation: Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Ajamete Kaykas,

    Affiliation: Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Ramanuj DasGupta,

    Affiliation: Department of Pharmacology and Cancer Institute, New York University School of Medicine, New York, New York, United States of America

    X
  • Randall T. Moon mail

    rtmoon@u.washington.edu

    Affiliation: Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Published: July 02, 2009
  • DOI: 10.1371/journal.pone.0006129

About the Authors

Lorna S. Kategaya, Travis Biechele, William H. Conrad, Ajamete Kaykas, Randall T. Moon
Department of Pharmacology, Howard Hughes Medical Institute (HHMI), University of Washington School of Medicine and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Binita Changkakoty, Ramanuj DasGupta
Department of Pharmacology and Cancer Institute, New York University School of Medicine, New York, New York, United States of America

Corresponding Author

Email: rtmoon@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LK TB AK RD RTM. Performed the experiments: LK BC TB WHC RD. Analyzed the data: LK TB RD RTM. Contributed reagents/materials/analysis tools: TB. Wrote the paper: LK TB RTM.