About the Authors

Xing Yang

Affiliations Shanghai Center for Bioinformation Technology, Shanghai, China, School of Life Science and Technology, Tongji University, Shanghai, China

Lu Xie

Affiliation Shanghai Center for Bioinformation Technology, Shanghai, China

Yixue Li

yxli@sibs.ac.cn (YXL); ccwei@sjtu.edu.cn (CCW)

Affiliations Shanghai Center for Bioinformation Technology, Shanghai, China, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China, Bioinformation Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Chaochun Wei

yxli@sibs.ac.cn (YXL); ccwei@sjtu.edu.cn (CCW)

Affiliations Shanghai Center for Bioinformation Technology, Shanghai, China, Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China, Lab of Molecular Microbial Ecology and Ecogenomics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived, designed and directed the research project: CW. Drafted the manuscript: CW XY. Revised the manuscript: CW LX YL. Developed and implemented the algorithm, collected datasets, and devised the gene counting model: XY. Participated in discussion: LX. Conceived and designed the research work: YL.