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Research Article

Interaction with LC8 Is Required for Pak1 Nuclear Import and Is Indispensable for Zebrafish Development

  • Christine M. Lightcap equal contributor,

    equal contributor Contributed equally to this work with: Christine M. Lightcap, Gabor Kari, Luis E. Arias-Romero

    Affiliation: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Gabor Kari equal contributor,

    equal contributor Contributed equally to this work with: Christine M. Lightcap, Gabor Kari, Luis E. Arias-Romero

    Affiliation: Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • Luis E. Arias-Romero equal contributor,

    equal contributor Contributed equally to this work with: Christine M. Lightcap, Gabor Kari, Luis E. Arias-Romero

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

    X
  • Jonathan Chernoff,

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

    X
  • Ulrich Rodeck,

    Affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    X
  • John C. Williams mail

    jwilliams@coh.org

    Affiliations: Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California, United States of America

    X
  • Published: June 26, 2009
  • DOI: 10.1371/journal.pone.0006025

About the Authors

Christine M. Lightcap, John C. Williams
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Gabor Kari
Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Luis E. Arias-Romero, Jonathan Chernoff
Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Ulrich Rodeck
Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
John C. Williams
Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California, United States of America

Corresponding Author

Email: jwilliams@coh.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JC UR JCW. Performed the experiments: CML GK LEAR. Analyzed the data: CML GK LEAR JC UR JCW. Contributed reagents/materials/analysis tools: CML GK LEAR JC. Wrote the paper: UR JCW.