About the Authors
- Julia Romanova
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Contributed equally to this work with: Julia Romanova, Brigitte M. Krenn
Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Brigitte M. Krenn
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Contributed equally to this work with: Julia Romanova, Brigitte M. Krenn
Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Markus Wolschek
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Affiliations Avir Green Hills Biotechnology AG, Vienna, Austria, Department of Surgery, University of Vienna Medical School, Vienna, Austria
- Boris Ferko
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Ekaterina Romanovskaja-Romanko
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Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia
- Alexander Morokutti
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Anna-Polina Shurygina
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Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia
- Sabine Nakowitsch
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Tanja Ruthsatz
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Bettina Kiefmann
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Ulrich König
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Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
- Michael Bergmann
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Affiliation Department of Surgery, University of Vienna Medical School, Vienna, Austria
- Monika Sachet
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Affiliation Department of Surgery, University of Vienna Medical School, Vienna, Austria
- Shobana Balasingam
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Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
- Alexander Mann
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Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
- John Oxford
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Affiliation Retroscreen Virology Ltd., Centre for Infectious Diseases, Bart's and the London, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
- Martin Slais
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Affiliation BioTest Ltd., Konarovice, Czech Republic
- Oleg Kiselev
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Affiliation Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia
- Thomas Muster
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Affiliations Avir Green Hills Biotechnology AG, Vienna, Austria, Division of General Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
- Andrej Egorov
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* E-mail: a.egorov@greenhillsbiotech.com
Affiliation Avir Green Hills Biotechnology AG, Vienna, Austria
Competing Interests
Avir Green Hills Biotechnology is a privately held biopharmaceutical company based in Vienna which draws its own knowledge in virology to develop and commercialize a vaccine approach targeting seasonal and pandemic influenza disease among other products in the pipeline. The primary objective of the projects FLUVACC (LSHB-CT-2005-518281) and Intranasal H5 Vaccine (SP5B-CT-2007-044512) related to this manuscript is the development of an intranasal live attenuated vaccine targeting pandemic influenza disease. Both projects are executed in collaboration with international partners, which form a consortium that is regulated by the projects' corresponding consortium agreements. The consortium agreement regulates the operational execution of the project, including protection, exploitation and use of knowledge. IIPR rights related to this manuscript are covered by the following IP rights: DelNs1 mutants are covered by patents from Avir Green Hills and Mount Sinai School of Medicine. Patent applications covering the technology platform of the influenza virus expression construct and virus amplification procedure are fully owned by Avir Green Hills Biotechnology. The patent application concerning the purification process is co-owned with Biaseparations d.r.o. All individuals named in the authorship list of this manuscript are either employees of Avir Green Hills Biotechnology or of organizations that have entered an agreement within the European grants mentioned above.
Author Contributions
Conceived and designed the experiments: JR BMK MW BF TR MMB SB AM JO MS OK TM AE. Performed the experiments: BMK MW BF ERR AM APS SN BK UK MS MS. Analyzed the data: JR BMK BF ERR AM APS SN TR BK UK MS TM. Contributed reagents/materials/analysis tools: MW MMB. Wrote the paper: JR BMK AE.