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Research Article

Divergent Cardiopulmonary Actions of Heme Oxygenase Enzymatic Products in Chronic Hypoxia

  • Sally H. Vitali,

    Affiliation: Division of Critical Care Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • S. Alex Mitsialis,

    Affiliation: Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Olin D. Liang,

    Affiliation: Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Xiaoli Liu,

    Affiliation: Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Angeles Fernandez-Gonzalez,

    Affiliation: Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Helen Christou,

    Affiliation: Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Xinqi Wu,

    Affiliation: Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Francis X. McGowan,

    Affiliation: Division of Cardiac Anesthesia, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Stella Kourembanas mail

    stella.kourembanas@childrens.harvard.edu

    Affiliation: Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America

    X
  • Published: June 19, 2009
  • DOI: 10.1371/journal.pone.0005978

About the Authors

Sally H. Vitali
Division of Critical Care Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America
S. Alex Mitsialis, Olin D. Liang, Angeles Fernandez-Gonzalez, Stella Kourembanas
Division of Newborn Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America
Xiaoli Liu
Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Helen Christou, Xinqi Wu
Division of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Francis X. McGowan
Division of Cardiac Anesthesia, Children's Hospital Boston, Boston, Massachusetts, United States of America

Corresponding Author

Email: stella.kourembanas@childrens.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: SV. Wrote the paper: SV. PI of laboratory, provided overall scientific direction and funded the research: SK. Edited the manuscript: SK SAM HC. Performed all animal experiments, cardiomyocyte work, proliferation studies: SV. Provided intellectual input, maintained HO-1 null line, engineered hypoxia chamber setup and software control, and taught several animal techniques to Dr. Vitali: SAM. Performed right ventricular pressure measurements for several experiments: ODL XL. Taught Dr. Vitali histological techniques and lung inflation: AFG. Analyzed pulmonary arteriolar remodeling: HC. Performed smooth muscle cell migration experiments: XW. Cardiac anesthesiologist who directed cardiomyocyte experiments: FXM.