Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2

Hwang-Phill Kim; Young-Kwang Yoon; Jin-Won Kim; Sae-Won Han; Hyung-Seok Hur; Jinah Park; Ju-Hee Lee; Do-Youn Oh; Seock-Ah Im; Yung-Jue Bang; Tae-You Kim

doi:10.1371/journal.pone.0005933

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Open Access

Peer-reviewed

Research Article

Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2

Hwang-Phill Kim,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Young-Kwang Yoon,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Jin-Won Kim,

Affiliation Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
Sae-Won Han,

Affiliation Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
Hyung-Seok Hur,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Jinah Park,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Ju-Hee Lee,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Do-Youn Oh,

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
Seock-Ah Im,

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
Yung-Jue Bang,

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
Tae-You Kim

* E-mail: kimty@snu.ac.kr

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯

Lapatinib, a Dual EGFR and HER2 Tyrosine Kinase Inhibitor, Downregulates Thymidylate Synthase by Inhibiting the Nuclear Translocation of EGFR and HER2

Hwang-Phill Kim,
Young-Kwang Yoon,
Jin-Won Kim,
Sae-Won Han,
Hyung-Seok Hur,
Jinah Park,
Ju-Hee Lee,
Do-Youn Oh,
Seock-Ah Im,
Yung-Jue Bang

Published: June 16, 2009
https://doi.org/10.1371/journal.pone.0005933

About the Authors

Hwang-Phill Kim

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Young-Kwang Yoon

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Jin-Won Kim

Affiliation Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Sae-Won Han

Affiliation Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Hyung-Seok Hur

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Jinah Park

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Ju-Hee Lee

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Do-Youn Oh

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Seock-Ah Im

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Yung-Jue Bang

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Tae-You Kim

* E-mail: kimty@snu.ac.kr

Affiliations Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HPK SWH YJB TYK. Performed the experiments: HPK YKY HSH. Analyzed the data: HPK YKY JWK SWH HSH JP JHL DYO SAI YJB TYK. Contributed reagents/materials/analysis tools: DYO SAI YJB TYK. Wrote the paper: HPK YJB TYK.

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Cancer treatment
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Breast cancer
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Gastric cancer
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Transfection
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Colorectal cancer
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Polymerase chain reaction
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EGFR signaling
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Gene expression
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