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Research Article

A Changing Gastric Environment Leads to Adaptation of Lipopolysaccharide Variants in Helicobacter pylori Populations during Colonization

  • Anna Skoglund equal contributor,

    equal contributor Contributed equally to this work with: Anna Skoglund, Helene Kling Bäckhed

    Affiliations: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, Swedish Institute for Infectious Disease Control, Solna, Sweden

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  • Helene Kling Bäckhed equal contributor,

    equal contributor Contributed equally to this work with: Anna Skoglund, Helene Kling Bäckhed

    Affiliations: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, Swedish Institute for Infectious Disease Control, Solna, Sweden

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  • Christina Nilsson,

    Affiliations: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, Swedish Institute for Infectious Disease Control, Solna, Sweden

    Current address: Genome Technology and Biology, Genome Institute of Singapore, Singapore, Singapore

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  • Britta Björkholm,

    Affiliation: Swedish Institute for Infectious Disease Control, Solna, Sweden

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  • Staffan Normark,

    Affiliations: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, Swedish Institute for Infectious Disease Control, Solna, Sweden

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  • Lars Engstrand mail

    lars.engstrand@smi.se

    Affiliations: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden, Swedish Institute for Infectious Disease Control, Solna, Sweden

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  • Published: June 11, 2009
  • DOI: 10.1371/journal.pone.0005885

About the Authors

Anna Skoglund, Helene Kling Bäckhed, Christina Nilsson, Staffan Normark, Lars Engstrand
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Anna Skoglund, Helene Kling Bäckhed, Christina Nilsson, Britta Björkholm, Staffan Normark, Lars Engstrand
Swedish Institute for Infectious Disease Control, Solna, Sweden

Corresponding Author

Email: lars.engstrand@smi.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS HKB SN LE. Performed the experiments: AS HKB. Analyzed the data: AS HKB CN BB SN. Contributed reagents/materials/analysis tools: SN LE. Wrote the paper: AS HKB CN BB SN LE.