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Research Article

Endotoxin Induced Chorioamnionitis Prevents Intestinal Development during Gestation in Fetal Sheep

  • Tim G. A. M. Wolfs,

    Affiliation: Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands

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  • Wim A. Buurman,

    Affiliation: Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands

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  • Bea Zoer,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands

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  • Rob M. J. Moonen,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands

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  • Joep P. M. Derikx,

    Affiliation: Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands

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  • Geertje Thuijls,

    Affiliation: Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands

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  • Eduardo Villamor,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands

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  • Markus Gantert,

    Affiliation: Department of Obstetrics & Gynecology, University of Cologne, Cologne, Germany

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  • Yves Garnier,

    Affiliation: Department of Obstetrics & Gynecology, University of Cologne, Cologne, Germany

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  • Luc J. I. Zimmermann,

    Affiliation: Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands

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  • Boris W. Kramer mail

    b.kramer@mumc.nl

    Affiliation: Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands

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  • Published: June 08, 2009
  • DOI: 10.1371/journal.pone.0005837

About the Authors

Tim G. A. M. Wolfs, Wim A. Buurman, Joep P. M. Derikx, Geertje Thuijls
Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands
Bea Zoer, Rob M. J. Moonen, Eduardo Villamor, Luc J. I. Zimmermann, Boris W. Kramer
Department of Pediatrics, Maastricht University Medical Center (MUMC), School of Oncology and Developmental Biology (GROW), Maastricht, the Netherlands
Markus Gantert, Yves Garnier
Department of Obstetrics & Gynecology, University of Cologne, Cologne, Germany

Corresponding Author

Email: b.kramer@mumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TGAMW WB LJIZ BWK. Performed the experiments: TGAMW BZ RMJM JD GT BWK. Analyzed the data: TGAMW WB BZ RMJM JD GT EV MG YG LJIZ BWK. Contributed reagents/materials/analysis tools: EV MG YG. Wrote the paper: TGAMW WB EV LJIZ BWK.