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Research Article

Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis

  • Valerie W. Hu mail,

    bcmvwh@gwumc.edu

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • AnhThu Nguyen,

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Kyung Soon Kim,

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

    Current address: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Mara E. Steinberg,

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Tewarit Sarachana,

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Michele A. Scully,

    Affiliation: Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Steven J. Soldin,

    Affiliation: Departments of Medicine, Pharmacology, and Oncology, Georgetown University Medical Center, Washington, D. C., United States of America

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  • Truong Luu,

    Affiliation: Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Norman H. Lee

    Affiliation: Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, D. C., United States of America

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  • Published: June 03, 2009
  • DOI: 10.1371/journal.pone.0005775

About the Authors

Valerie W. Hu, AnhThu Nguyen, Kyung Soon Kim, Mara E. Steinberg, Tewarit Sarachana, Michele A. Scully
Department of Biochemistry and Molecular Biology, The George Washington University Medical Center, Washington, D. C., United States of America
Steven J. Soldin
Departments of Medicine, Pharmacology, and Oncology, Georgetown University Medical Center, Washington, D. C., United States of America
Truong Luu, Norman H. Lee
Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, D. C., United States of America

Corresponding Author

Email: bcmvwh@gwumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VWH. Performed the experiments: AN KSK MES MAS SJS. Analyzed the data: VWH. Contributed reagents/materials/analysis tools: VWH. Wrote the paper: VWH. Analyzed the microarray data: VWH. Prepared functional genomics schematic (Fig. 5): TS. Performed steroid analyses: SJS. Responsible for printing and quality control of the DNA microarray slides: TL. Contributed to the discussion and editing of the manuscript: NHL. Performed the microarray experiments: KSK MAS. Performed qRT-PCR analyses: AN. Assisted in sample and manuscript preparation: MES. Constructed the biochemical network shown in Fig. 5: TS. Responsible for the steroid hormone analyses: SJS. Responsible for printing and quality control of the DNA microarray slides: TL. Contributed to the discussion and editing of the manuscript: NHL.