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Research Article

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

  • Lichuan Yang,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Noel Y. Calingasan,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Bobby Thomas,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Rajnish K. Chaturvedi,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Mahmoud Kiaei,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Elizabeth J. Wille,

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Karen T. Liby,

    Affiliation: Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Charlotte Williams,

    Affiliation: Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Darlene Royce,

    Affiliation: Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Renee Risingsong,

    Affiliation: Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Eric S. Musiek,

    Affiliation: Department of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Jason D. Morrow,

    Affiliation: Department of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Michael Sporn,

    Affiliation: Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • M. Flint Beal mail

    fbeal@med.cornell.edu

    Affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America

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  • Published: June 01, 2009
  • DOI: 10.1371/journal.pone.0005757

About the Authors

Lichuan Yang, Noel Y. Calingasan, Bobby Thomas, Rajnish K. Chaturvedi, Mahmoud Kiaei, Elizabeth J. Wille, M. Flint Beal
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York, United States of America
Karen T. Liby, Charlotte Williams, Darlene Royce, Renee Risingsong, Michael Sporn
Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
Eric S. Musiek, Jason D. Morrow
Department of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Author

Email: fbeal@med.cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LY MFB. Performed the experiments: LY NC BT RKC MK EJW KTL CW DR RR ESM JDM MBS MFB. Analyzed the data: LY NC JDM MBS MFB. Contributed reagents/materials/analysis tools: JDM MBS MFB. Wrote the paper: LY MFB.