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Research Article

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

  • Erik Kvam,

    Affiliations: Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

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  • Brent L. Nannenga,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Min S. Wang,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Zongjian Jia,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Michael R. Sierks,

    Affiliation: Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

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  • Anne Messer mail

    messer@wadsworth.org

    Affiliations: Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America

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  • Published: May 28, 2009
  • DOI: 10.1371/journal.pone.0005727

About the Authors

Erik Kvam, Anne Messer
Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
Erik Kvam, Anne Messer
Department of Biomedical Sciences, University at Albany, Albany, New York, United States of America
Brent L. Nannenga, Min S. Wang, Zongjian Jia, Michael R. Sierks
Department of Chemical Engineering, Arizona State University, Tempe, Arizona, United States of America

Corresponding Author

Email: messer@wadsworth.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EK BLN MRS AM. Performed the experiments: EK BLN MSW ZJ. Analyzed the data: EK BLN MSW ZJ MRS AM. Contributed reagents/materials/analysis tools: MRS. Wrote the paper: EK AM.