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Research Article

Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis

  • Michael P. Walsh,

    Affiliation: Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America

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  • Ashish Chintakuntlawar,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Christopher M. Robinson,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ijad Madisch,

    Affiliation: Insitut für Virologie, Medizinische Hochschule, Hannover, Germany

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  • Balázs Harrach,

    Affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary

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  • Nolan R. Hudson,

    Affiliation: Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, California, United States of America

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  • David Schnurr,

    Affiliation: Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, California, United States of America

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  • Albert Heim,

    Affiliation: Insitut für Virologie, Medizinische Hochschule, Hannover, Germany

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  • James Chodosh,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Donald Seto,

    Affiliation: Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America

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  • Morris S. Jones mail

    drmorrisj@yahoo.com

    Affiliation: Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, California, United States of America

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  • Published: June 03, 2009
  • DOI: 10.1371/journal.pone.0005635

About the Authors

Michael P. Walsh, Donald Seto
Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America
Ashish Chintakuntlawar, Christopher M. Robinson, James Chodosh
Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America
Ijad Madisch, Albert Heim
Insitut für Virologie, Medizinische Hochschule, Hannover, Germany
Balázs Harrach
Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
Nolan R. Hudson, Morris S. Jones
Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, California, United States of America
David Schnurr
Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, California, United States of America

Corresponding Author

Email: drmorrisj@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM DS AH JC DS MSJ. Performed the experiments: MPW AVC CMR IM NRH. Analyzed the data: MPW AVC CMR IM BH DS AH JC DS MSJ. Contributed reagents/materials/analysis tools: DS AH JC DS MSJ. Wrote the paper: MPW AVC CMR IM BH DS AH JC DS MSJ.