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Research Article

Attaching and Effacing Escherichia coli Downregulate DNA Mismatch Repair Protein In Vitro and Are Associated with Colorectal Adenocarcinomas in Humans

  • Oliver D. K. Maddocks mail,

    olivermaddocks@yahoo.co.uk

    Affiliations: Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom, Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Abigail J. Short,

    Affiliation: Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Michael S. Donnenberg,

    Affiliation: Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Scott Bader,

    Affiliation: Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • David J. Harrison

    Affiliation: Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Published: May 13, 2009
  • DOI: 10.1371/journal.pone.0005517

About the Authors

Oliver D. K. Maddocks, Abigail J. Short, Scott Bader, David J. Harrison
Division of Pathology, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
Oliver D. K. Maddocks, Michael S. Donnenberg
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: olivermaddocks@yahoo.co.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ODKM AJS SB DJH. Performed the experiments: ODKM AJS SB. Analyzed the data: ODKM AJS MSD SB DJH. Contributed reagents/materials/analysis tools: MSD DJH. Wrote the paper: ODKM. Responsible for substantial contribution to the conception and design: DJH SB ODKM. Responsible for substation contribution to the analysis and interpretation of data: DJH SB MSD AJS ODKM. Responsible for revising the manuscript critically for important intellectual content: DJH SB MSD AJS. Responsible for final approval of the version to be published: DJH SB MSD AJS ODKM. Responsible for the acquisition of data: SB AJS ODKM. Responsible for drafting the article: ODKM.