Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

Maria Xilouri; Tereza Vogiatzi; Kostas Vekrellis; David Park; Leonidas Stefanis

doi:10.1371/journal.pone.0005515

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Open Access

Peer-reviewed

Research Article

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

Maria Xilouri ,

Contributed equally to this work with: Maria Xilouri, Tereza Vogiatzi

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
⨯
Tereza Vogiatzi ,

Contributed equally to this work with: Maria Xilouri, Tereza Vogiatzi

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
⨯
Kostas Vekrellis,

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
⨯
David Park,

Affiliation Neuroscience Lab, University of Ottawa, Ottawa, Ontario, Canada
⨯
Leonidas Stefanis

* E-mail: lstefanis@bioacademy.gr

Affiliations Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, Second Department of Neurology, University of Athens Medical School, Athens, Greece
⨯

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

Maria Xilouri,
Tereza Vogiatzi,
Kostas Vekrellis,
David Park,
Leonidas Stefanis

Published: May 13, 2009
https://doi.org/10.1371/journal.pone.0005515

About the Authors

Maria Xilouri

Contributed equally to this work with: Maria Xilouri, Tereza Vogiatzi

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Tereza Vogiatzi

Contributed equally to this work with: Maria Xilouri, Tereza Vogiatzi

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Kostas Vekrellis

Affiliation Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

David Park

Affiliation Neuroscience Lab, University of Ottawa, Ottawa, Ontario, Canada

Leonidas Stefanis

* E-mail: lstefanis@bioacademy.gr

Affiliations Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, Second Department of Neurology, University of Athens Medical School, Athens, Greece

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MX Kv LS. Performed the experiments: MX TV Kv. Analyzed the data: MX TV Kv. Contributed reagents/materials/analysis tools: DSP. Wrote the paper: MX TV Kv LS.

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Lysosomes
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Small interfering RNA
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Neuronal differentiation
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Neurons
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Proteolysis
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Autophagic cell death
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Transfection
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Neuronal death
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