Mammalian MCM Loading in Late-G1 Coincides with Rb Hyperphosphorylation and the Transition to Post-Transcriptional Control of Progression into S-Phase

Piyali Mukherjee; Thinh V. Cao; Sherry L. Winter; Mark G. Alexandrow

doi:10.1371/journal.pone.0005462

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Peer-reviewed

Research Article

Mammalian MCM Loading in Late-G₁ Coincides with Rb Hyperphosphorylation and the Transition to Post-Transcriptional Control of Progression into S-Phase

Piyali Mukherjee ,

Contributed equally to this work with: Piyali Mukherjee, Thinh V. Cao

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America
⨯
Thinh V. Cao ,

Contributed equally to this work with: Piyali Mukherjee, Thinh V. Cao

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America
⨯
Sherry L. Winter,

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America
⨯
Mark G. Alexandrow

* E-mail: Mark.Alexandrow@Moffitt.org

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America
⨯

Mammalian MCM Loading in Late-G₁ Coincides with Rb Hyperphosphorylation and the Transition to Post-Transcriptional Control of Progression into S-Phase

Piyali Mukherjee,
Thinh V. Cao,
Sherry L. Winter,
Mark G. Alexandrow

Published: May 7, 2009
https://doi.org/10.1371/journal.pone.0005462

About the Authors

Piyali Mukherjee

Contributed equally to this work with: Piyali Mukherjee, Thinh V. Cao

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America

Thinh V. Cao

Contributed equally to this work with: Piyali Mukherjee, Thinh V. Cao

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America

Sherry L. Winter

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America

Mark G. Alexandrow

* E-mail: Mark.Alexandrow@Moffitt.org

Affiliation Program in Molecular Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PM TVC MGA. Performed the experiments: PM TVC. Analyzed the data: PM TVC MGA. Contributed reagents/materials/analysis tools: MGA. Wrote the paper: SLW MGA.

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Synthesis phase
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CHO cells
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Messenger RNA
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Chromatin
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Cyclins
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Cell cycle and cell division
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Phosphorylation
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Transcriptional control
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