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Research Article

Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model

  • Jianfeng Liu,

    Affiliation: Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Xin Gu,

    Affiliation: Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Delira Robbins,

    Affiliation: Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Guohong Li,

    Affiliation: Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Runhua Shi,

    Affiliation: Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Joe M. McCord,

    Affiliation: Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

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  • Yunfeng Zhao mail

    yzhao1@lsuhsc.edu

    Affiliation: Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

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  • Published: April 22, 2009
  • DOI: 10.1371/journal.pone.0005284

About the Authors

Jianfeng Liu, Delira Robbins, Yunfeng Zhao
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
Xin Gu
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
Guohong Li
Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
Runhua Shi
Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
Joe M. McCord
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

Corresponding Author

Email: yzhao1@lsuhsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ. Performed the experiments: JL XG DR. Analyzed the data: GL RS. Contributed reagents/materials/analysis tools: JM. Wrote the paper: JM YZ.