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Research Article

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

  • Christelle Cabrol,

    Affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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  • Malwina A. Huzarska,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Christopher Dinolfo,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Maria C. Rodriguez,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

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  • Lael Reinstatler,

    Affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

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  • Jake Ni,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Li-An Yeh,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Gregory D. Cuny,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Ross L. Stein,

    Affiliation: Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

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  • Dennis J. Selkoe,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Malcolm A. Leissring mail

    Leissring@mayo.edu

    Affiliations: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: April 22, 2009
  • DOI: 10.1371/journal.pone.0005274

About the Authors

Christelle Cabrol, Lael Reinstatler, Malcolm A. Leissring
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
Malwina A. Huzarska, Christopher Dinolfo, Maria C. Rodriguez, Malcolm A. Leissring
Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America
Jake Ni, Li-An Yeh, Gregory D. Cuny, Ross L. Stein
Laboratory for Drug Discovery, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America
Dennis J. Selkoe, Malcolm A. Leissring
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: Leissring@mayo.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LAY GC RLS DJS MAL. Performed the experiments: CC MAH CD MCR LR JN MAL. Analyzed the data: CC CD GC RLS MAL. Wrote the paper: RLS DJS MAL.