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Research Article

A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity

  • Iana Parvanova,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

    Current address: Division of Molecular Pathobiology, Department of Clinical Research and VPH, Vetsuisse Faculty Bern, Bern, Switzerland

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  • Sabrina Epiphanio,

    Affiliation: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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  • Abdul Fauq,

    Affiliation: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, Florida, United States of America

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  • Todd E. Golde,

    Affiliation: Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, Florida, United States of America

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  • Miguel Prudêncio,

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Maria M. Mota mail

    mmota@fm.ul.pt

    Affiliations: Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

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  • Published: April 01, 2009
  • DOI: 10.1371/journal.pone.0005078

About the Authors

Iana Parvanova, Sabrina Epiphanio, Miguel Prudêncio, Maria M. Mota
Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
Abdul Fauq, Todd E. Golde
Department of Neuroscience, Mayo Clinic, College of Medicine, Jacksonville, Florida, United States of America
Miguel Prudêncio, Maria M. Mota
Instituto Gulbenkian de Ciência, Oeiras, Portugal

Corresponding Author

Email: mmota@fm.ul.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IP MMM. Performed the experiments: IP SE MP. Analyzed the data: IP SE MP MMM. Contributed reagents/materials/analysis tools: AF TG. Wrote the paper: IP MP MMM.