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Research Article

The Vibrio cholerae Cytolysin Promotes Chloride Secretion from Intact Human Intestinal Mucosa

  • Lucantonio Debellis equal contributor,

    equal contributor Contributed equally to this work with: Lucantonio Debellis, Anna Diana

    Affiliation: Department of General and Environmental Physiology, University of Bari, Bari, Italy

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  • Anna Diana equal contributor,

    equal contributor Contributed equally to this work with: Lucantonio Debellis, Anna Diana

    Affiliation: Department of General and Environmental Physiology, University of Bari, Bari, Italy

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  • Diletta Arcidiacono,

    Affiliation: Venetian Institute of Molecular Medicine, Padua, Italy

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  • Romina Fiorotto,

    Affiliation: Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Piero Portincasa,

    Affiliation: Clinica Medica “A. Murri”, Department of Internal and Public Medicine, University Medical School, Bari, Italy

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  • Donato Francesco Altomare,

    Affiliation: Department of Emergency and Organ Transplantation, General Surgery and Liver Transplantation Units, University of Bari, Policlinico, Bari, Italy

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  • Carlo Spirlì,

    Affiliation: Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Marina de Bernard mail

    marina.debernard@unipd.it

    Affiliations: Venetian Institute of Molecular Medicine, Padua, Italy, Department of Biology, University of Padua, Padua, Italy

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  • Published: March 31, 2009
  • DOI: 10.1371/journal.pone.0005074

About the Authors

Lucantonio Debellis, Anna Diana
Department of General and Environmental Physiology, University of Bari, Bari, Italy
Diletta Arcidiacono, Marina de Bernard
Venetian Institute of Molecular Medicine, Padua, Italy
Romina Fiorotto, Carlo Spirlì
Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America
Piero Portincasa
Clinica Medica “A. Murri”, Department of Internal and Public Medicine, University Medical School, Bari, Italy
Donato Francesco Altomare
Department of Emergency and Organ Transplantation, General Surgery and Liver Transplantation Units, University of Bari, Policlinico, Bari, Italy
Marina de Bernard
Department of Biology, University of Padua, Padua, Italy

Corresponding Author

Email: marina.debernard@unipd.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LD AD DA CS MDB. Performed the experiments: LD AD DA RF. Analyzed the data: LD CS MDB. Contributed reagents/materials/analysis tools: LD PP DFA MDB. Wrote the paper: LD MDB.