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Research Article

Ser/Thr/Tyr Protein Phosphorylation in the Archaeon Halobacterium salinarum—A Representative of the Third Domain of Life

  • Michalis Aivaliotis equal contributor mail,

    equal contributor Contributed equally to this work with: Michalis Aivaliotis, Boris Macek

    michalis@biochem.mpg.de

    Affiliation: Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany

    Current address: Center of Basic Research II, Biomedical Research Centre of Academy of Athens, Athens, Greece

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  • Boris Macek equal contributor,

    equal contributor Contributed equally to this work with: Michalis Aivaliotis, Boris Macek

    Affiliation: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

    Current address: Proteome Center, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany

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  • Florian Gnad,

    Affiliation: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Peter Reichelt,

    Affiliation: Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany

    Current address: Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Matthias Mann,

    Affiliation: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Dieter Oesterhelt

    Affiliation: Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Published: March 10, 2009
  • DOI: 10.1371/journal.pone.0004777

About the Authors

Michalis Aivaliotis, Peter Reichelt, Dieter Oesterhelt
Department of Membrane Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany
Boris Macek, Florian Gnad, Matthias Mann
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany

Corresponding Author

Email: michalis@biochem.mpg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA DO. Performed the experiments: MA BM. Analyzed the data: MA BM FG. Contributed reagents/materials/analysis tools: MA BM FG PR. Wrote the paper: MA. Provided the infrastructure and the knowledge for the phosphopeptide enrichment and the mass spectrometry: MM. Provided the infrastructure and the knowledge for the phosphoproteome analysis of the halophilic archaea: DO.