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Research Article

Core-Shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers

  • Caterina Longo,

    Affiliations: Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy, Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Alexis Patanarut,

    Affiliation: Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America

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  • Tony George,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Barney Bishop,

    Affiliation: Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America

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  • Weidong Zhou,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Claudia Fredolini,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Mark M. Ross,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Virginia Espina,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Giovanni Pellacani,

    Affiliation: Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy

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  • Emanuel F. Petricoin III,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Lance A. Liotta,

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Alessandra Luchini mail

    aluchini@gmu.edu

    Affiliation: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America

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  • Published: March 10, 2009
  • DOI: 10.1371/journal.pone.0004763

About the Authors

Caterina Longo, Giovanni Pellacani
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
Caterina Longo, Tony George, Weidong Zhou, Claudia Fredolini, Mark M. Ross, Virginia Espina, Emanuel F. Petricoin III, Lance A. Liotta, Alessandra Luchini
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, United States of America
Alexis Patanarut, Barney Bishop
Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America

Corresponding Author

Email: aluchini@gmu.edu

Competing Interests

The technology described herein is licensed (patent pending) to the authors institutions (George Mason University, USA and Istituto Superiore di Sanita', Italy). Under faculty guidelines the University authors can received a share of the patent royalties owned by the university.

Author Contributions

Conceived and designed the experiments: CL CF GP EP LL AL. Performed the experiments: CL AP TG WZ AL. Analyzed the data: MMR. Contributed reagents/materials/analysis tools: BB CF VE. Wrote the paper: CL VE LL AL.